TUMOR MARKERS

S. No. Tumor Marker Cancer Type Tissue Analyzed Purpose
1. ALK gene

Rearrangement

Non-small cell

Lung cancer: anaplastic

Large cell lymphoma

Tumor tissue To help determine treatment and prognosis
2. Alpha(AFPX0.64IU/L) Liver cancer: germ cell tumors Blood To help diagnose fetoprotein liver cancer and follow response to treatment: to assess stage, prognosis, and response to treatment.
3. Beta 2 microglobulin Multiple myeloma: chronic lymphocytic leukemia Blood, urine and CSF To determine prognosis and to follow response to treatment
4. Beta human chorionic gonadotropin(Beta-hCG) Choriocarcinoma: testicular cancer Urine or blood To assess the stage, prognosis, and response to treatment
5. BCR- ABL Chronic myeloid leukemia Blood or bone marrow To confirm diagnosis and monitor disease status
6. CA 15-3

CA 27.29

Breast cancer Blood To assess treatment is effective and disease has recurred
7. CA 19-9 Pancreatic cancer, Gallbladder cancer, Bile duct cancer, Gastric cancer Blood To assess treatment is working or not
8. CA 125 Ovarian cancer Blood To help in diagnosis, assessment of response to treatment, and evaluation of recurrence
9. Calcitonin Medullary thyroid Blood To aid in cancer diagnosis, treatment is working or not, assess recurrence
10. Carcinoembryonic antigen (CEA) Colorectal cancer

Breast cancer

Blood To check cancer has spread

To look breast for breast cancer recurrence and assess the response of treatment

11. CD 20 Non-Hodgkin lymphoma Blood Determine treatment with targeted therapy is appropriate
12. Chromogranin A (CgA) Neuroendocrine Blood Tumor diagnosis, assessment of treatment response, and evaluation of recurrence
13. Chromosomes

3,7,17 and 9p21

Bladder cancer Urine Monitoring for tumor recurrence
14. Cytokeratin  Fragments 21-1 Lung cancer Blood Monitoring for recurrence
15. EGFR mutation analysis Non-small cell tumor tissue Determine lung cancer treatment and prognosis
16. Estrogen receptor (ER)

Progesterone receptor (PR)

Breast cancer Tumor tissue Determine whether treatment with hormonal therapy is appropriate
17. Fibrin/fibrinogen Bladder cancer Urine Monitor progression and response to treatment
18. HE4 Ovarian cancer Blood Assess disease progression and monitor recurrence
19. HER2/neu Breast cancer, gastric cancer, esophageal cancer Tumor tissue Determine treatment with Trastuzumab is appropriate
20. Immunoglobulins Multiple myeloma:

Waldenstrom macroglobulinemia

Blood and urine Diagnose disease, assess response to treatment and recurrence
21. KIT Gastrointestinal stromal tumor: mucosal melanoma Tumor tissue Diagnose and determine treatment
22. KRAS mutation Colorectal cancer:

non-small cell

lung cancer

Tumor tissue Analysis whether treatment with a particular type of targeted therapy is appropriate
23. Lactate dehydrogenase Germ cell tumor Blood assess the stage Assess stage, prognosis and response treatment
24. Nuclear matrix Bladder cancer Urine Monitor protein 22 response to treatment
25. Prostate specific Prostate cancer Blood Diagnose, assess antigen (PSA) response to (<5ng/ml) treatment and recurrence
26. Thyroglobulin Thyroid cancer Tumor tissue To evaluate response to treatment and to look recurrence
27. Urokinase plasminogen activator (uP A) and plasminogen activator inhibitor (PAI-1) Breast cancer Tumor tissue Determine aggressiveness of cancer
28. 70- Gene signature (Mammaprint) Breast cancer Tumor tissue To evaluate risk of recurrence
29. 21-|Gene signature (Oncotype DX) Breast cancer Tumor tissue  
30. 5- protein Ovarian cancer Blood Preoperatively signature assess pelvic mass for suspected ovarian cancer

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