Tag: Regulatory T Cells And Chemokines For Lymphocyte Recruitment In Cutaneous Lupus Erythematosus

Naturally arising CD4+CD25+ regulatory T cells (Treg) represent a major lymphocyte population actively maintaining immunological tolerance to self and non-self-antigens. In the experimental mouse model of LE (NZB/ NZW F1), the frequency of Treg is lower than in control animals. Recently, a decreased number of peripheral Treg was also found in SLE patients and a significant correlation was…